The Béthanie was built in 1875 by the French Society of Foreign Missions as their first sanatorium in East Asia, where missionaries infected with tropical diseases could convalesce before returning to their work. From 1875 until its closure in 1974, the Béthanie received around 6000 missionaries and served as an important base for the missionary work of the French Catholic church in East Asia. The Béthanie was later taken over by the Government and leased to The University of Hong Kong from 1978 to 1997. In 2002, the Government leased The Béthanie to The Hong Kong Academy for Performing Arts as its second campus. The Béthanie Campus received an Honourable Mention in the 2008 UNESCO Asia-Pacific Awards for Cultural Heritage Conservation.

The Hong Kong Branch of the First Church of Christ, Scientist, originated from Boston in United States, was formed in 1905. It began holding worshipping gatherings in a small meeting house in Zetland Street in Central. The Church later acquired the site at No. 31 MacDonnell Road in 1910 and built the permanent church premises in 1912 with donations from church members. The Church was looted, and books and records were destroyed during the Japanese Occupation. After the Occupation, the Church was renovated and then resumed services. In 1956, a two-storey annex was constructed to cope with the growth of its services. A few major renovation works were later carried out at the Church building. The Church building at MacDonnell Road is the only church of the First Church of Christ, Scientist in Hong Kong.

The Old Dairy Farm Depot was built in 1892 for storing milk produced from the Dairy Farm at Pok Fu Lam. Dairy Farm relocated its head office to this depot building in 1896 and opened its first retail store on the ground floor in 1904. The original depot only comprised about half of the area of the present premises (approximately the area of the south block). Later, it was put under a number of extension and refurbishment works. The depot served as Dairy Farm’s head office until the 1970s. In 1984, the south block was leased to the Fringe Club for arts and cultural purposes. Since then, the site has been used as a venue for exhibitions, performances and cultural events, and is an iconic landmark in Central for arts and cultural exchange between the East and West.

The historic building on No. 7 Cox’s Road, built between 1902 and 1903, was originally a private residence until 1912 when the Government acquired the building and converted it into the Manager’s House of the Kowloon-Canton Railway. In 1928, the building was further converted to accommodate the Kowloon Junior School until its relocation in 1950. The building was later converted to the Portuguese Community School (also known as Escola Camões) in 1954. Operated under the Portuguese Community Education and Welfare Foundation, the School offered kindergarten and primary education services. In 1997, the Foundation returned the school premises to the Government, which then became the Po Leung Kuk Portuguese Community School up to 2012. It survives as a historical corroboration of the presence of the Portuguese community in Hong Kong. The building has been revitalised into the HKRep Education Hub in 2024 for promoting local theatrical art.

Founded in 1906 by the Church Missionary Society of the Anglican Church of England, St. Stephen's Girls’ College was originally located on Caine Road but moved to its present site on Lyttelton Road in 1923. During the Japanese Occupation, the school was used by the Japanese army as an “Emergency Hospital”. The College was one of the first schools to devote itself to the education of girls in Hong Kong, and some of its students were the first female graduates of The University of Hong Kong. The Main Building of the College is a four-storey structure. Its pitched roof rests on a timber truss system covered with Chinese pan-and-roll tiles. The design concept and layout of this building, which are similar to a traditional Chinese courtyard house, are distinctive.

Ohel Leah Synagogue was built in 1901. Jacob Elias Sassoon (1843-1916), along with his brothers, donated the land for the Synagogue and funded its construction entirely at his own expense. The Sassoons, of Iraqi-Jewish heritage, dedicated the Synagogue to the memory of their mother, Leah. Sir Matthew Nathan, the only Jewish Governor of Hong Kong, was appointed as the Honorary President of the Ohel Leah Synagogue during the period of his tenure (1904-1907). Dedicated to serving the Hong Kong Jewish community, Ohel Leah Synagogue is the only purpose-built synagogue ever constructed in Hong Kong. In 2000, the Synagogue received the Outstanding Project Award in the UNESCO Asia-Pacific Awards for Cultural Heritage Conservation.